Phosphorus oxychloride → 2-Chloro-4-methylquinazoline

HRID 1531749Notes

Reaction equation

HRID 1531749 reaction equation

[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4](=O)[N:3]=1.P(Cl)(Cl)([Cl:15])=O>Cl>[Cl:15][C:4]1[N:3]=[C:2]([CH3:1])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178433509HCID 178433509, compound

Product 1

HCID 152695802-Chloro-4-methylquinazoline

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Prepared analogously to Example 27c from 4-methyl-1H-quinazolin-2-one and phosphorus oxychloride in hydrochloric acid.

Sources & evidence

ORD record: ord-d39b378130fb47bb8622abeca03fe552
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06200976B1

Reaction notes

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