Phenylurea → HCID 21251008, compound

HRID 1531834Notes

Reaction equation

HRID 1531834 reaction equation
O[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[C:9]1([NH:15][C:16]([NH2:18])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(O)CCCCC>>[C:2]1([N:15]2[C:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[NH:18][C:16]2=[O:17])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6145PhenylureaHCID 81031-HexanolHCID 10785Cyclohexanone, 2-hydroxy-

Product 1

HCID 21251008HCID 21251008, compoundYield 29.6%

Procedure

A mixture of 4.5 g (39.4 mmol) of 2-hydroxycyclohexanone, 7.5 g (55 mmol) of phenylurea and 7 ml of hexanol is stirred under reflux for 20 hours. The mixture is concentrated under vacuum and the solid residue is recrystallized from acetone, and 2.5 g of product, m.p.=220° C., are recovered. Yield—29.6%.

Workup

  1. temperatureunder reflux for 20 hours
  2. concentrationThe mixture is concentrated under vacuum
  3. customthe solid residue is recrystallized from acetone, and 2.5 g of product, m.p.=220° C.
  4. customare recovered

Sources & evidence

ORD record
ord-97df9e49459e4439b29fe93617e7becd
Source dataset
uspto-grants-2001_03
Patent number
US06200991B1

Reaction notes

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