Lithium hydroxide, monohydrate → HCID 9954196, compound

HRID 1531911Notes

Reaction equation

HRID 1531911 reaction equation
[CH:1]1[C:13]2[CH:12]([C:14]3[C:15](=[S:32])[NH:16][C:17](=[O:31])[N:18]([CH2:20][C:21]4[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=4)[C:24]([O:26]C)=[O:25])[CH:19]=3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.O.[OH-].[Li+]>O1CCCC1.O>[CH:10]1[C:11]2[CH:12]([C:14]3[C:15](=[S:32])[NH:16][C:17](=[O:31])[N:18]([CH2:20][C:21]4[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=4)[C:24]([OH:26])=[O:25])[CH:19]=3)[C:13]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[C:6]=2[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 131722425HCID 131722425, compound

Product 1

HCID 9954196HCID 9954196, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the product from step (v) (0.175 g) and lithium hydroxide monohydrate (0.034 g) in tetrahydrofuran (3 ml) and water (3 ml) was stirred at room temperature for 3 hours and partitioned between dichloromethane and 2 M HCl. The organic phase was dried (MgSO4) and evaporated under reduced pressure. Yield 0.095 g.

Workup

  1. custompartitioned between dichloromethane and 2 M HCl
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-ba922c3c097e4e7cabd65ca863a55cca
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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