Pyridine → HCID 131722445, compound

HRID 1531942Notes

Reaction equation

HRID 1531942 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]([CH:20]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH2:18]O)[CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])=[O:5])[CH3:2].[Cl:33]C(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl.N1C=CC=CC=1>O1CCCC1>[Cl:33][CH2:18][C:16]1[CH:15]=[C:10]([CH:9]=[C:8]([N:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:17]=1)[C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 1049PyridineHCID 94429TriphosgeneHCID 131722443HCID 131722443, compound

Product 1

HCID 131722445HCID 131722445, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of step (v) (0.5 g) in tetrahydrofuran (20 ml) was treated with triphosgene (0.114 g) then pyridine (0.183 g). After 16 hours the reaction was evaporated and purified by chromatography eluting with 20% ethyl acetate in isohexane. Yield 0.4 g.

Workup

  1. customAfter 16 hours the reaction was evaporated
  2. custompurified by chromatography
  3. washeluting with 20% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-502a3e1dbf1042e9a43c30916717f965
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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