反应详情

温度

50 °C

To a solution of 4-phenoxy-2-propylphenol (PCT Application WO97/28115) in DMF was added potassium carbonate and allyl bromide. The reaction was stirred for 5 h at 50° C., and after cooling was neutralized with 1N HCl and extracted with ethyl acetate. The organic extract was washed with brine, dried over magnessium sulphate, filtered and concentrated to afford an oil which was chromatographed on silica gel (15% ethyl acetate:hexanes) to afford 2-propyl-4-phenoxyphenyl allyl ether.

1. temperatureafter cooling
2. extractionextracted with ethyl acetate
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried over magnessium sulphate
6. filtrationfiltered
7. concentrationconcentrated
8. customto afford an oil which
9. customwas chromatographed on silica gel (15% ethyl acetate:hexanes)