反应详情

To a solution of (2-hydroxyphenyl)acetic acid (125 g) in dimethylformamide (1.9 l) was added potassium carbonate (909 g) and benzyl bromide (281 g) successively. After being stirred for 18 hours, the mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed with 1N aqueous sodium hydroxide solution and brine, dried and evaporated in vacuo. Dichloromethane was added to the residue and the solution was treated with activated carbon. The mixture was filtered and evaporated to give benzyl (2-benzyloxyphenyl)acetate (132 g).

1. filtrationthe mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with 1N aqueous sodium hydroxide solution and brine
5. customdried
6. customevaporated in vacuo
7. additionDichloromethane was added to the residue
8. additionthe solution was treated with activated carbon
9. filtrationThe mixture was filtered
10. customevaporated