Bromide ion → 2-(4-Chloro-3-fluorophenyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid
Reaction equation
[Br-:24].[C:32]([O:33][CH3:34])([CH3:35])([CH3:36])[CH3:37].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:38][C:39]#[N:40].[Cl:1][c:2]1[c:3]([F:22])[cH:4][c:5]([CH:8]2[N:9]([C:18](=[O:19])[O:20][CH3:21])[CH2:10][CH2:11][CH:12]([C:14](=[O:15])[O:16][CH3:17])[CH2:13]2)[cH:6][cH:7]1.[Li+:23].[OH2:41]>>[Cl:1][c:2]1[c:3]([F:22])[cH:4][c:5]([CH:8]2[N:9]([C:18](=[O:19])[O:20][CH3:21])[CH2:10][CH2:11][CH:12]([C:14](=[O:15])[OH:16])[CH2:13]2)[cH:6][cH:7]1Participants
8
Sources & evidence
- ORD record
- ord-d65ea06c1888490b8df0f34020f2a896
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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