Hydrochloric Acid → 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline

HRID 153368Notes

Reaction equation

HRID 153368 reaction equation
[CH2:25]([N:26]([CH2:27][CH3:28])[CH2:29][CH3:30])[CH3:31].[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8](=[O:23])[nH:9][c:10](-[c:13]3[c:14]([C:19]([F:20])([F:21])[F:22])[cH:15][cH:16][cH:17][cH:18]3)[n:11][c:12]12.[ClH:24].[P:32]([Cl:33])([Cl:34])([Cl:35])=[O:36]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8]([Cl:34])[n:9][c:10](-[c:13]3[c:14]([C:19]([F:20])([F:21])[F:22])[cH:15][cH:16][cH:17][cH:18]3)[n:11][c:12]12

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 24813Phosphorus oxychlorideHCID 1358508318-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one

Product 1

HCID 219392374-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline

Sources & evidence

ORD record
ord-285c00c9c8a948a6bdf37d80fbb816d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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