1-Butanol → HCID 12227892, compound

HRID 1533895Notes

Reaction equation

HRID 1533895 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7]Cl.[F:9][C:10]1[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=1)[NH2:13].C(=O)([O-])[O-].[K+].[K+].C(O)CCC>CO.O.C(OCC)C>[ClH:2].[F:9][C:10]1[CH:11]=[C:12]([N:13]2[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]2)[CH:14]=[CH:15][CH:16]=1

Participants

6

Reactant 4

HCID 2631-ButanolHCID 97423-FluoroanilineHCID 11430Potassium CarbonateHCID 522769Bis(2-chloroethyl)amine hydrochloride

Product 1

HCID 12227892HCID 12227892, compoundYield 35.9%

Reagents, catalysts & solvents 1

HCID 86745446HCID 86745446, compoundSolvent

Procedure

This compound was prepared according to the procedure of Preparation 1. A mixture of 8.0 g (0.045 mol) of bis(2-chloroethyl)amine hydrochloride, 5.0 g (0.045 mol) of m-fluoroaniline and 12.5 g (0.09 mol) of solid potassium carbonate in a total volume of 50 mL of n-butanol gave 3.5 g (35%) of white solid, mp 205°-207° C. (methanol-water-ethyl ether).

Workup

  1. customThis compound was prepared
  2. customaccording to the procedure of Preparation 1

Sources & evidence

ORD record
ord-6db1d895c8d54ee7b58a5475cbb53e94
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Reaction notes

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