Hydrochloric Acid → 1-(2-Fluorophenyl)piperazine Hydrochloride

HRID 1533897Notes

Reaction equation

HRID 1533897 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7]Cl.[F:9][C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12].C(=O)([O-])[O-].[K+].[K+].Cl>C(O)CCC>[ClH:2].[F:9][C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[N:12]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 95842-FluoroanilineHCID 11430Potassium CarbonateHCID 522769Bis(2-chloroethyl)amine hydrochloride

Product 1

HCID 27346981-(2-Fluorophenyl)piperazine HydrochlorideYield 20.5%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure used in Preparation 1. A mixture of 15.1 g (0.09 mol) of bis(2-chloroethyl)amine hydrochloride, 10.0 g (0.09 mol) of 2-fluoroaniline and 25.0 g of solid potassium carbonate in a total volume of 100 mL of 1-butanol gave an oil as residue. The oil was converted to the hydrochloric acid salt (ethereal HCl) and recrystallized from methanol-ether to give 4.0 g (20%) of white solid, mp 185°-187° C.

Workup

  1. customThis compound was prepared
  2. customused in Preparation 1
  3. customgave an oil as residue
  4. customrecrystallized from methanol-ether

Sources & evidence

ORD record
ord-e3a4a92b30114fa282f3d907c01a4262
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Reaction notes

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