Tert-Butylamine → HCID 14880461, compound

HRID 1533978Notes

Reaction equation

HRID 1533978 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)=[O:13])=[CH:8][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:29]([NH2:33])([CH3:32])([CH3:31])[CH3:30]>C(O)C>[CH3:30][C:29]([NH:33][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)=[O:13])=[CH:8][CH:7]=1)([CH3:32])[CH3:31]

Participants

5

Reactant 3

HCID 6385Tert-ButylamineHCID 11430Potassium CarbonateHCID 14880460HCID 14880460, compound

Product 1

HCID 14880461HCID 14880461, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 7.75 g of the product of Step E, 6.83 g of potassium carbonate, 25.8 ml of tertbutylamine and 150 ml of ethanol was heated at 140° C. for 48 hours in an autoclave. After filtering, the filtrate was brought to dryness under reduced pressure and the 11.7 g of residue were chromatographed of silica (eluant: ethyl acetate-triethylamine (95-5)) to obtain 6.32 g of the desired product.

Workup

  1. filtrationAfter filtering
  2. customthe 11.7 g of residue were chromatographed of silica (eluant: ethyl acetate-triethylamine (95-5))

Sources & evidence

ORD record
ord-e97b3018a02645d5889ed7335284af0c
Source dataset
uspto-grants-1992_02
Patent number
US05086070

Reaction notes

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