Water → 5-(t-butoxycarbonyl-N-methylamino)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

HRID 1535015Notes

Reaction equation

HRID 1535015 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[CH:13]1[N:19]([CH3:22])[CH2:20][CH2:21][C:12]21[CH3:23])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:24][Si]([N-][Si](C)(C)C)(C)C.[Li+].COS(OC)(=O)=O.O>C1COCC1.C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[CH:13]1[N:19]([CH3:22])[CH2:20][CH2:21][C:12]21[CH3:23])[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

7

Reactant 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 2733832Lithium HexamethyldisilazideHCID 19908910HCID 19908910, compound

Product 1

HCID 199089055-(t-butoxycarbonyl-N-methylamino)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent3×HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
-78 °C

Procedure

5-(t-Butyloxycarbonylamino)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole (1.7 g) was dissolved in dry THF (15 ml) under nitrogen and cooled to -78° C. in a dry ice/acetone bath. A 1M solution of lithium bis(trimethylsilyl)amide (7.2 ml) in THF was added via a syringe. The solution was stirred at -78° C. for 15 minutes, warmed to room temperature and again cooled to -78° C. before the addition of dimethylsulfate (0.74 g) in THF (5 ml) via syringe. The mixture was stirred for 1 hour and allowed to warm to ambient temperature and water was added in order to quench the reaction. Ethyl acetate (100 ml) was added and the mixture was washed with brine (20 ml), dried (Na2SO4), concentrated and purified by flash chromatography (eluting with 15% MeOH/EtOAc). The pure fractions were concentrated to give 5-(t-butoxycarbonyl-N-methylamino)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole (0.42 g).

Workup

  1. temperaturewarmed to room temperature
  2. stirringThe mixture was stirred for 1 hour
  3. temperatureto warm to ambient temperature
  4. customto quench
  5. customthe reaction
  6. washthe mixture was washed with brine (20 ml)
  7. dry with materialdried (Na2SO4)
  8. concentrationconcentrated
  9. custompurified by flash chromatography (eluting with 15% MeOH/EtOAc)
  10. concentrationThe pure fractions were concentrated

Sources & evidence

ORD record
ord-fde11436744a418ba32008b5f00e4578
Source dataset
uspto-grants-1992_02
Patent number
US05091541

Reaction notes

Loading…