Tetrahydrofuran → 5-Nitro-3-(phenylethynyl)pyridin-2-amine

HRID 153607Notes

Reaction equation

[CH3:12][CH2:13][N:14]([CH2:15][CH3:16])[CH2:17][CH3:18].[Cu:32][I:33].[NH2:1][c:2]1[n:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[cH:6][c:7]1[Br:8].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[c:19]1([C:25]#[CH:26])[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[cH:6][c:7]1[C:26]#[C:25][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 10821Phenylacetylene

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 27344122-Amino-3-bromo-5-nitropyridine

Product 1

HCID 593229015-Nitro-3-(phenylethynyl)pyridin-2-amine

Sources & evidence

ORD record: ord-3cdab77e1f7445e2a8e9b1ce19ff7496
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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