Trifluoroacetic acid → 4-[2-(2-Aminopyrimidin-5-yl)-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]piperazine-1-carboaldehyde
Reaction equation
[CH3:57][CH2:58][O:59][C:60](=[O:61])[CH3:62].[F:12][C:13]([F:14])([F:15])[C:16]([OH:17])=[O:18].[O:19]1[CH2:20][CH2:21][N:22]([c:25]2[c:26]3[n:27][c:28]([N:46]4[CH2:47][CH2:48][NH:49][CH2:50][CH2:51]4)[n:29]([CH2:41][C:42]([F:43])([F:44])[F:45])[c:30]3[n:31][c:32](-[c:34]3[cH:35][n:36][c:37]([NH2:40])[n:38][cH:39]3)[n:33]2)[CH2:23][CH2:24]1.[O:52]1[CH2:53][CH2:54][CH2:55][CH2:56]1.[n:1]1([CH:10]=[O:11])[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8][n:9]1>>[CH:10](=[O:11])[N:49]1[CH2:48][CH2:47][N:46]([c:28]2[n:27][c:26]3[c:25]([N:22]4[CH2:21][CH2:20][O:19][CH2:24][CH2:23]4)[n:33][c:32](-[c:34]4[cH:35][n:36][c:37]([NH2:40])[n:38][cH:39]4)[n:31][c:30]3[n:29]2[CH2:41][C:42]([F:43])([F:44])[F:45])[CH2:51][CH2:50]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-53dbf5d22c5e4831a27785f927219bef
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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