Acetic Acid → 5-Chloro-3-methoxypyrazine-2-carbaldehyde

HRID 1538518Notes

Reaction equation

HRID 1538518 reaction equation
[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH3:1][C:2]1([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[NH:10]1.[CH3:25][N:26]([CH:27]=[O:28])[CH3:29].[CH3:36][C:37](=[O:38])[OH:39].[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[Cl:16][c:17]1[n:18][c:19]([O:23][CH3:24])[cH:20][n:21][cH:22]1.[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1.[OH2:35]>>[Cl:16][c:17]1[n:18][c:19]([O:23][CH3:24])[c:20]([CH:27]=[O:28])[n:21][cH:22]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 962WaterHCID 1140TolueneHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 130352,2,6,6-TetramethylpiperidineHCID 110189992-Chloro-6-methoxypyrazineHCID 178418339Butyllithium

Product 1

HCID 222479455-Chloro-3-methoxypyrazine-2-carbaldehyde

Sources & evidence

ORD record
ord-512ac8e79d6f46a488efd0409d3b008c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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