Dimethylformamide → 2-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-N-((5-fluoropyridin-3-yl)methyl)-4-methylthiazole-5-carboxamide

HRID 1538669Notes

Reaction equation

HRID 1538669 reaction equation
[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH3:60][N:61]([CH3:62])[CH:63]=[O:64].[CH3:65][CH2:66][O:67][C:68](=[O:69])[CH3:70].[CH:1]1([CH2:4][N:5]2[C:6](=[O:19])[N:7]([c:10]3[s:11][c:12]([C:16](=[O:17])[OH:18])[c:13]([CH3:15])[n:14]3)[CH2:8][CH2:9]2)[CH2:2][CH2:3]1.[F:51][c:52]1[cH:53][c:54]([CH2:58][NH2:59])[cH:55][n:56][cH:57]1.[P-:20]([F:21])([F:22])([F:23])([F:24])([F:25])[F:26].[n:27]1([O:28][C:29]([N:30]([CH3:31])[CH3:32])=[N+:33]([CH3:34])[CH3:35])[c:36]2[n:37][cH:38][cH:39][cH:40][c:41]2[n:42][n:43]1>>[CH:1]1([CH2:4][N:5]2[C:6](=[O:19])[N:7]([c:10]3[s:11][c:12]([C:16](=[O:18])[NH:59][CH2:58][c:54]4[cH:53][c:52]([F:51])[cH:57][n:56][cH:55]4)[c:13]([CH3:15])[n:14]3)[CH2:8][CH2:9]2)[CH2:2][CH2:3]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 45116207(5-Fluoropyridin-3-yl)methanamineHCID 579198202-(3-(Cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Product 1

HCID 579200012-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-N-((5-fluoropyridin-3-yl)methyl)-4-methylthiazole-5-carboxamide

Sources & evidence

ORD record
ord-1ea6af7efbdd4f5593a4405ee633270f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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