Acetic Acid → [2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-(4,4-difluoro-cyclohexyl)-acetic acid
Reaction equation
[CH2:1]([N:2]([N:3]=[O:4])[C:9]([CH:10]([CH:11]1[CH2:12][CH2:13][C:14]([F:17])([F:18])[CH2:15][CH2:16]1)[n:19]1[c:20](-[c:30]2[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]2)[n:21][c:22]2[c:23]1[cH:24][c:25]([F:29])[c:26]([F:28])[cH:27]2)=[O:37])[c:5]1[cH:6][cH:7][cH:8][cH:38][cH:39]1.[CH3:45][C:46]([OH:47])=[O:48].[Li+:42].[O:49]1[CH2:50][CH2:51][CH2:52][CH2:53]1.[OH-:41].[OH2:40].[OH2:54].[OH:43][OH:44]>>[C:9]([CH:10]([CH:11]1[CH2:12][CH2:13][C:14]([F:17])([F:18])[CH2:15][CH2:16]1)[n:19]1[c:20](-[c:30]2[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]2)[n:21][c:22]2[c:23]1[cH:24][c:25]([F:29])[c:26]([F:28])[cH:27]2)(=[O:37])[OH:47]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-409d3ccd252c48a79009f2790647134a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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