1,2-Dichloroethane → 7-Benzyloxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline

HRID 1541959Notes

Reaction equation

HRID 1541959 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([O:20][CH:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[c:12]2[c:13](=[O:19])[nH:14][cH:15][n:16][c:17]2[cH:18]1.[CH:32]([N:33]([CH:34]([CH3:35])[CH3:36])[CH2:37][CH3:38])([CH3:39])[CH3:40].[Cl:41][CH2:42][CH2:43][Cl:44].[P:27]([Cl:28])([Cl:29])([Cl:30])=[O:31]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([O:20][CH:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[c:12]2[c:13]([Cl:29])[n:14][cH:15][n:16][c:17]2[cH:18]1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 1358309117-Benzyloxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one

Product 1

HCID 221408227-Benzyloxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline

Sources & evidence

ORD record
ord-cc6f5916911e4c3fa2fe8f983163ee6f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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