Pyridine → 3-Chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)picolinamide

HRID 1543374Notes

Reaction equation

HRID 1543374 reaction equation
[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[Cl:19][C:20]([C:21]([Cl:22])=[O:23])=[O:24].[Cl:50][CH2:51][Cl:52].[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:18])[c:10]([C:15](=[O:16])[OH:17])[c:11]([I:14])[cH:12][cH:13]2)[cH:6][cH:7]1.[NH2:25][c:26]1[cH:27][c:28]([F:43])[c:29]([O:30][c:31]2[c:32]([Cl:40])[c:33]([C:37](=[O:38])[NH2:39])[n:34][cH:35][cH:36]2)[cH:41][cH:42]1.[O:53]=[CH:54][N:55]([CH3:56])[CH3:57].[cH:44]1[cH:45][cH:46][n:47][cH:48][cH:49]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:18])[c:10]([C:15](=[O:17])[NH:25][c:26]3[cH:27][c:28]([F:43])[c:29]([O:30][c:31]4[c:32]([Cl:40])[c:33]([C:37](=[O:38])[NH2:39])[n:34][cH:35][cH:36]4)[cH:41][cH:42]3)[c:11]([I:14])[cH:12][cH:13]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 1049PyridineHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 252319754-(4-Amino-2-fluorophenoxy)-3-chloropicolinamideHCID 595946501-(4-Fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Product 1

HCID 595946493-Chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)picolinamide

Sources & evidence

ORD record
ord-12ce55e701ad4ba1bc9a242dc333fc73
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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