Dimethylformamide → Methyl 6-bromo-2-[(4-carbamoylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylate

HRID 1546669Notes

Reaction equation

HRID 1546669 reaction equation
[C:33]([Cl:34])(=[O:35])[C:36]([Cl:37])=[O:38].[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6]([CH2:23][c:24]2[cH:25][cH:26][c:27]([C:30](=[O:31])[OH:32])[cH:28][cH:29]2)[c:7](=[O:22])[c:8]2[cH:9][cH:10][c:11]([Br:21])[cH:12][c:13]2[c:14]1-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6]([CH2:23][c:24]2[cH:25][cH:26][c:27]([C:30](=[O:31])[NH2:40])[cH:28][cH:29]2)[c:7](=[O:22])[c:8]2[cH:9][cH:10][c:11]([Br:21])[cH:12][c:13]2[c:14]1-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 102890466-bromo-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

Product 1

HCID 10311178Methyl 6-bromo-2-[(4-carbamoylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylate

Sources & evidence

ORD record
ord-3f68089a1d6248db8e85e4413dc6c938
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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