4-Bromotoluene → 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol
Reaction equation
[Br:2][c:3]1[cH:4][cH:5][c:6]([CH3:9])[cH:7][cH:8]1.[CH2:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[N:17]1[CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[Mg:1]>>[c:3]1([C:20]2([OH:23])[CH2:19][CH2:18][N:17]([CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[CH2:22][CH2:21]2)[cH:4][cH:5][c:6]([CH3:9])[cH:7][cH:8]1Participants
5
Sources & evidence
- ORD record
- ord-273046f6e643440da0c93d35d5a81d60
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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