Tetrahydrofuran → 5-Bromo-2-((tert-butyldimethylsilyl)ethynyl)pyridine

HRID 1550360Notes

Reaction equation

HRID 1550360 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[C:9]([CH3:10])([CH3:11])([CH3:12])[Si:13]([CH3:14])([CH3:15])[C:16]#[CH:17].[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[Cu:30][I:31]>>[c:2]1([C:17]#[C:16][Si:13]([C:9]([CH3:10])([CH3:11])[CH3:12])([CH3:14])[CH3:15])[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 693532,5-DibromopyridineHCID 2757281(tert-Butyldimethylsilyl)acetylene

Product 1

HCID 666112135-Bromo-2-((tert-butyldimethylsilyl)ethynyl)pyridine

Sources & evidence

ORD record
ord-53d2a1e8217e4616bbb8b47ebdc771e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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