Tetrahydrofuran → 1-Difluoromethoxy-4-{3-[3-(2-methoxy-ethyl)-cyclobutyl]phenyl-ethynyl}benzene
Reaction equation
[Br:45][c:46]1[cH:47][cH:48][c:49]([O:52][CH:53]([F:54])[F:55])[cH:50][cH:51]1.[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[CH3:1][O:2][CH2:3][CH2:4][CH:5]1[CH2:6][CH:7]([c:9]2[cH:10][c:11]([C:15]#[C:16][Si:17]([CH:18]([CH3:19])[CH3:20])([CH:21]([CH3:22])[CH3:23])[CH:24]([CH3:25])[CH3:26])[cH:12][cH:13][cH:14]2)[CH2:8]1.[CH3:28][CH2:29][CH2:30][CH2:31][N+:32]([CH2:33][CH2:34][CH2:35][CH3:36])([CH2:37][CH2:38][CH2:39][CH3:40])[CH2:41][CH2:42][CH2:43][CH3:44].[CH3:56][CH2:57][N:58]([CH2:59][CH3:60])[CH2:61][CH3:62].[Cu:68]([I:69])[I:70].[F-:27].[cH:71]1[cH:72][cH:73][c:74]([P:75]([Pd:76]([P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([P:96]([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)[P:115]([c:116]2[cH:117][cH:118][cH:119][cH:120][cH:121]2)([c:122]2[cH:123][cH:124][cH:125][cH:126][cH:127]2)[c:128]2[cH:129][cH:130][cH:131][cH:132][cH:133]2)([c:134]2[cH:135][cH:136][cH:137][cH:138][cH:139]2)[c:140]2[cH:141][cH:142][cH:143][cH:144][cH:145]2)[cH:146][cH:147]1>>[CH3:1][O:2][CH2:3][CH2:4][CH:5]1[CH2:6][CH:7]([c:9]2[cH:10][c:11]([C:15]#[C:16][c:46]3[cH:47][cH:48][c:49]([O:52][CH:53]([F:54])[F:55])[cH:50][cH:51]3)[cH:12][cH:13][cH:14]2)[CH2:8]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-f7899412e33046438e03bbae4ec5e003
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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