Tetrahydrofuran → 6-Methoxy-10-(4-methoxy-phenyl)-9-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene

HRID 1551767Notes

Reaction equation

HRID 1551767 reaction equation
[Al+3:38].[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:14]([cH:15][cH:16]1)[CH:13]([CH2:17][O:18][S:19]([c:20]1[cH:21][cH:22][c:23]([CH3:24])[cH:25][cH:26]1)(=[O:27])=[O:28])[CH:12]([c:29]1[cH:30][cH:31][c:32]([O:35][CH3:36])[cH:33][cH:34]1)[CH:11]1[CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10]1.[CH3:48][CH2:49][O:50][C:51](=[O:52])[CH3:53].[H-:37].[H-:40].[H-:41].[H-:42].[Li+:39].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:14]([cH:15][cH:16]1)[CH:13]([CH3:17])[CH:12]([c:29]1[cH:30][cH:31][c:32]([O:35][CH3:36])[cH:33][cH:34]1)[CH:11]1[CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 72309434Toluene-4-sulfonic acid 6-methoxy-10-(4-methoxy-phenyl)-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-9-ylmethyl ester

Product 1

HCID 666519736-Methoxy-10-(4-methoxy-phenyl)-9-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene

Sources & evidence

ORD record
ord-cefeb2be2b5949eb8f005e3d8576c894
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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