Tetrahydrofuran → 4-[1-[6-(2,4-Difluorophenyl)pyridin-2-yl]-2-oxo-4-(trimethylsilyl)but-3-yn-1-yl]-3,5-difluorobenzonitrile
Reaction equation
[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:26][Si:27]([N-:28][Si:29]([CH3:30])([CH3:31])[CH3:32])([CH3:33])[CH3:34].[CH3:36][Si:37]([C:38]#[C:39][C:40](=[O:41])[O:42][CH2:43][CH3:44])([CH3:45])[CH3:46].[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][cH:12][c:13]([CH2:15][c:16]3[c:17]([F:25])[cH:18][c:19]([C:20]#[N:21])[cH:22][c:23]3[F:24])[n:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Li+:35]>>[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][cH:12][c:13]([CH:15]([c:16]3[c:17]([F:25])[cH:18][c:19]([C:20]#[N:21])[cH:22][c:23]3[F:24])[C:40]([C:39]#[C:38][Si:37]([CH3:36])([CH3:45])[CH3:46])=[O:41])[n:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-4376dc3f8494432abd4f6ce8991197cb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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