Tetrahydrofuran → Trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4,4-difluoro-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester
Reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:16][CH:17]([N-:18][CH:19]([CH3:20])[CH3:21])[CH3:22].[Cl:23][c:24]1[cH:25][c:26]([O:37][S:38](=[O:39])(=[O:40])[C:41]([F:42])([F:43])[F:44])[cH:27][c:28]([Cl:36])[c:29]1[CH2:30][O:31][S:32]([CH3:33])(=[O:34])=[O:35].[F:1][C:2]1([F:14])[CH2:3][CH2:4][CH:5]([N:8]2[C:9](=[O:13])[CH2:10][CH2:11][CH2:12]2)[CH2:6][CH2:7]1.[Li+:15]>>[F:1][C:2]1([F:14])[CH2:3][CH2:4][CH:5]([N:8]2[C:9](=[O:13])[CH:10]([CH2:30][c:29]3[c:24]([Cl:23])[cH:25][c:26]([O:37][S:38](=[O:39])(=[O:40])[C:41]([F:42])([F:43])[F:44])[cH:27][c:28]3[Cl:36])[CH2:11][CH2:12]2)[CH2:6][CH2:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-07ad5262f73e403b8582d0c60578bed4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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