Tetrahydrofuran → N-[6-[(tert-butylamino)methyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-2-[2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-1-yl]acetamide

HRID 155674Notes

Reaction equation

HRID 155674 reaction equation
[C:57]([CH3:58])([CH3:59])([CH3:60])[NH:61][CH2:62][c:63]1[cH:64][c:65]2[c:70]([cH:71][cH:72]1)[CH:69]([NH2:73])[CH2:68][CH2:67][CH2:66]2.[CH2:74]1[O:75][CH2:76][CH2:77][CH2:78]1.[CH3:79][CH2:80][O:81][C:82](=[O:83])[CH3:84].[CH:24]([N:25]([CH2:26][CH3:27])[CH:28]([CH3:29])[CH3:30])([CH3:31])[CH3:32].[P-:33]([F:34])([F:35])([F:36])([F:37])([F:38])[F:39].[S:1](=[O:2])(=[O:3])([c:4]1[cH:5][cH:6][c:7]([CH3:8])[cH:9][cH:10]1)[N:11]1[CH:12]([CH2:20][C:21](=[O:22])[OH:23])[c:13]2[n:14]([cH:17][cH:18][cH:19]2)[CH2:15][CH2:16]1.[n:40]1([O:41][C:42]([N:43]([CH3:44])[CH3:45])=[N+:46]([CH3:47])[CH3:48])[c:49]2[n:50][cH:51][cH:52][cH:53][c:54]2[n:55][n:56]1>>[S:1](=[O:2])(=[O:3])([c:4]1[cH:5][cH:6][c:7]([CH3:8])[cH:9][cH:10]1)[N:11]1[CH:12]([CH2:20][C:21](=[O:22])[NH:73][CH:69]2[CH2:68][CH2:67][CH2:66][c:65]3[cH:64][c:63]([CH2:62][NH:61][C:57]([CH3:58])([CH3:59])[CH3:60])[cH:72][cH:71][c:70]32)[c:13]2[n:14]([cH:17][cH:18][cH:19]2)[CH2:15][CH2:16]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 59486400HCID 59486400, compoundHCID 697546756-[(Tert-butylamino)methyl]-1,2,3,4-tetrahydronaphthalen-1-amine

Product 1

HCID 46909088N-[6-[(tert-butylamino)methyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-2-[2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-1-yl]acetamide

Sources & evidence

ORD record
ord-3009d44f904045d39a67c67122075935
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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