Acetate → 6-(Benzenesulfonyl)-8-benzyl-4'-[2-methyl-5-(trifluoromethoxy)-2,3-dihydro-1-benzofuran-7-yl]-1-phenylspiro[8-azabicyclo[3.2.1]octane-2,2'-oxolane]
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:29]3[cH:30][cH:31][cH:32][cH:33][cH:34]3)[C:10]3([CH2:11][CH2:12][CH:13]1[CH:14]([S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH2:15]2)[O:25][CH2:26][CH:27]=[CH:28]3.[CH2:58]([N+:59]([CH2:60][CH2:61][CH2:62][CH3:63])([CH2:64][CH2:65][CH2:66][CH3:67])[CH2:68][CH2:69][CH2:70][CH3:71])[CH2:72][CH2:73][CH3:74].[CH3:84][N:85]([CH3:86])[CH:87]=[O:88].[CH:53]([O-:54])=[O:55].[Cl-:52].[Cl-:57].[I:35][c:36]1[cH:37][c:38]([O:46][C:47]([F:48])([F:49])[F:50])[cH:39][c:40]2[c:44]1[O:43][CH:42]([CH3:45])[CH2:41]2.[K+:56].[Li+:51].[O-:76][C:77]([CH3:78])=[O:79].[O-:80][C:81]([CH3:82])=[O:83].[OH2:89].[Pd+2:75]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:29]3[cH:30][cH:31][cH:32][cH:33][cH:34]3)[C:10]3([CH2:11][CH2:12][CH:13]1[CH:14]([S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH2:15]2)[O:25][CH2:26][CH:27]([c:36]1[cH:37][c:38]([O:46][C:47]([F:48])([F:49])[F:50])[cH:39][c:40]2[c:44]1[O:43][CH:42]([CH3:45])[CH2:41]2)[CH2:28]3Participants
12
Reactant 11
HCID 175Acetate2×
HCID 283Formate
HCID 312Chloride2×
HCID 813Potassium Cation
HCID 962Water
HCID 6228Dimethylformamide
HCID 16028Tetrabutylammonium
HCID 28486Lithium ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 184034062,3-Dihydro-7-iodo-2-methyl-5-trifluoromethoxybenzofuran
HCID 701526176'-(benzenesulfonyl)-8'-benzyl-1'-phenylspiro[2H-furan-5,2'-8-azabicyclo[3.2.1]octane]Product 1
Sources & evidence
- ORD record
- ord-163a956f2d024a85badcc570759061f7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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