Methanol → 3-{[5-(3-Methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]methyl}-2-oxopyrrolidine-3-carboxylic acid
Reaction equation
[CH3:1][c:2]1[cH:3][c:4](-[c:19]2[cH:20][n:21][c:22]([CH2:24][C:25]3([C:31](=[O:32])[O:33][CH2:34][CH3:35])[C:26](=[O:30])[NH:27][CH2:28][CH2:29]3)[s:23]2)[cH:5][c:6]([NH:8][c:9]2[n:10][cH:11][cH:12][c:13]([C:15]([F:16])([F:17])[F:18])[n:14]2)[cH:7]1.[CH3:41][OH:42].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[Li+:43].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1.[OH-:44].[OH2:51]>>[CH3:1][c:2]1[cH:3][c:4](-[c:19]2[cH:20][n:21][c:22]([CH2:24][C:25]3([C:31](=[O:32])[OH:33])[C:26](=[O:30])[NH:27][CH2:28][CH2:29]3)[s:23]2)[cH:5][c:6]([NH:8][c:9]2[n:10][cH:11][cH:12][c:13]([C:15]([F:16])([F:17])[F:18])[n:14]2)[cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-c6f3d64f0a804138bcf5ca9c02c65a24
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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