Ammonium → 2-[5-Formyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 1563270Notes

Reaction equation

HRID 1563270 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[n:14]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH3:26])[c:15]([Br:18])[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1.[C:34]([O-:35])(=[O:36])[OH:37].[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:27][CH2:28][CH2:29][CH2:30][Li:31].[CH3:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54].[Cl-:32].[NH4+:33].[Na+:38].[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[n:14]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH3:26])[c:15]([CH:34]=[O:35])[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1

Participants

10

Reactant 9

HCID 223AmmoniumHCID 312ChlorideHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 574202132-[5-Bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 178418339Butyllithium

Product 1

HCID 723380662-[5-Formyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-49c8a25f7c6f4191af5637abb92d4754
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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