Tetrahydrofuran → 5-(benzyloxy)-1'-[(5-chloro-2-thienyl)methyl]spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 156485Notes

Reaction equation

HRID 156485 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([OH:34])[c:13]([C:15]2([CH2:32][OH:33])[C:16](=[O:31])[N:17]([CH2:24][c:25]3[s:26][c:27]([Cl:30])[cH:28][cH:29]3)[c:18]3[cH:19][cH:20][cH:21][cH:22][c:23]32)[cH:14]1.[CH2:35]([P:36]([CH2:37][CH2:38][CH2:39][CH3:40])[CH2:41][CH2:42][CH2:43][CH3:44])[CH2:45][CH2:46][CH3:47].[N:48]([C:49]([O:50][C:51]([CH3:52])([CH3:53])[CH3:54])=[O:55])=[N:56][C:57]([O:58][C:59]([CH3:60])([CH3:61])[CH3:62])=[O:63].[O:64]1[CH2:65][CH2:66][CH2:67][CH2:68]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([cH:14]1)[C:15]1([C:16](=[O:31])[N:17]([CH2:24][c:25]3[s:26][c:27]([Cl:30])[cH:28][cH:29]3)[c:18]3[cH:19][cH:20][cH:21][cH:22][c:23]31)[CH2:32][O:33]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 673797413-[5-(benzyloxy)-2-hydroxyphenyl]-1-[(5-chloro-2-thienyl)methyl]-3-hydroxymethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 461943035-(benzyloxy)-1'-[(5-chloro-2-thienyl)methyl]spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-ea2331d04e76402f9dddf77dc17a31e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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