3-Hydroxypyridine → 4-Tert-butyl 1-benzyl 2-((pyridin-3-yloxy)methyl)piperazine-1,4-dicarboxylate

HRID 1565429Notes

Reaction equation

HRID 1565429 reaction equation
[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[OH:1][CH2:2][CH:3]1[N:4]([C:16](=[O:17])[O:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[CH2:5][CH2:6][N:7]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:8]1.[OH:26][c:27]1[cH:28][n:29][cH:30][cH:31][cH:32]1.[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1>>[O:1]([CH2:2][CH:3]1[N:4]([C:16](=[O:17])[O:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[CH2:5][CH2:6][N:7]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:8]1)[c:27]1[cH:28][n:29][cH:30][cH:31][cH:32]1

Participants

5

Reactant 4

HCID 79713-HydroxypyridineHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 235310394-(1,1-Dimethylethyl) 1-(phenylmethyl) 2-(hydroxymethyl)-1,4-piperazinedicarboxylate

Product 1

HCID 596715754-Tert-butyl 1-benzyl 2-((pyridin-3-yloxy)methyl)piperazine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-cc67805b58414d8fbf6dfe3dcb9929bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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