Acetic Acid → 3-(2-(1,3-difluoropropan-2-yloxy)acetyl)dihydro-2H-pyran-4(3H)-one

HRID 1566664Notes

Reaction equation

HRID 1566664 reaction equation
[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH3:33][C:34](=[O:35])[OH:36].[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[CH3:9][Si:10]([N-:11][Si:12]([CH3:13])([CH3:14])[CH3:15])([CH3:16])[CH3:17].[F:23][CH2:24][CH:25]([CH2:26][F:27])[O:28][CH2:29][C:30](=[O:31])[Cl:32].[Li+:8].[O:1]1[CH2:2][CH2:3][C:4](=[O:7])[CH2:5][CH2:6]1.[OH2:44]>>[O:1]1[CH2:2][CH:3]([C:30]([CH2:29][O:28][CH:25]([CH2:24][F:23])[CH2:26][F:27])=[O:31])[C:4](=[O:7])[CH2:5][CH2:6]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 962WaterHCID 1140TolueneHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 121599Tetrahydro-4H-pyran-4-oneHCID 3280088Npc316347HCID 86641918HCID 86641918, compound

Product 1

HCID 593337623-(2-(1,3-difluoropropan-2-yloxy)acetyl)dihydro-2H-pyran-4(3H)-one

Sources & evidence

ORD record
ord-12cd90e909234166b0e6ae6e26c771b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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