Water → 3-(2,2-dimethyl-3-oxo-4H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-[(3-methoxy-2-propoxyphenyl)methyl]-N-methylprop-2-enamide

HRID 1567884Notes

Reaction equation

HRID 1567884 reaction equation
[CH3:16][C:17]1([CH3:33])[C:18](=[O:32])[NH:19][c:20]2[c:21]([cH:23][c:24]([CH:27]=[CH:28][C:29](=[O:30])[OH:31])[cH:25][n:26]2)[O:22]1.[CH3:1][O:2][c:3]1[c:4]([O:12][CH2:13][CH2:14][CH3:15])[c:5]([CH2:6][NH:7][CH3:8])[cH:9][cH:10][cH:11]1.[CH3:53][N:54]([CH3:55])[CH2:56][CH2:57][CH2:58][N:59]=[C:60]=[N:61][CH2:62][CH3:63].[CH:44]([N:45]([CH:46]([CH3:47])[CH3:48])[CH2:49][CH3:50])([CH3:51])[CH3:52].[O:64]=[CH:65][N:66]([CH3:67])[CH3:68].[OH2:69].[OH:34][n:35]1[c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]2[n:42][n:43]1>>[CH3:1][O:2][c:3]1[c:4]([O:12][CH2:13][CH2:14][CH3:15])[c:5]([CH2:6][N:7]([CH3:8])[C:29]([CH:28]=[CH:27][c:24]2[cH:23][c:21]3[c:20]([n:26][cH:25]2)[NH:19][C:18](=[O:32])[C:17]([CH3:16])([CH3:33])[O:22]3)=[O:31])[cH:9][cH:10][cH:11]1

Participants

8

Reactant 7

HCID 962WaterHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 28338626(3-Methoxy-2-propoxybenzyl)methylamineHCID 669676363-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-acrylic acid

Product 1

HCID 669672173-(2,2-dimethyl-3-oxo-4H-pyrido[3,2-b][1,4]oxazin-7-yl)-N-[(3-methoxy-2-propoxyphenyl)methyl]-N-methylprop-2-enamide

Sources & evidence

ORD record
ord-bf91492d3b5945fe9545203ada943b36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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