Water → 7-methyl-N8-(3-(6-(methylamino)pyrimidin-4-yl)pyridin-2-yl)-N4-(3-(trifluoromethyl)phenyl)quinazoline-4,8-diamine
Reaction equation
[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([NH:13][c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[n:7][cH:8][n:9][c:10]2[c:11]1[NH2:12].[CH3:39][Si:40]([N-:41][Si:42]([CH3:43])([CH3:44])[CH3:45])([CH3:46])[CH3:47].[CH3:55][CH2:56][O:57][C:58](=[O:59])[CH3:60].[Cl:24][c:25]1[n:26][cH:27][cH:28][cH:29][c:30]1-[c:31]1[cH:32][c:33]([NH:37][CH3:38])[n:34][cH:35][n:36]1.[Li+:48].[O:61]1[CH2:62][CH2:63][O:64][CH2:65][CH2:66]1.[OH2:54]>>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([NH:13][c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[n:7][cH:8][n:9][c:10]2[c:11]1[NH:12][c:25]1[n:26][cH:27][cH:28][cH:29][c:30]1-[c:31]1[cH:32][c:33]([NH:37][CH3:38])[n:34][cH:35][n:36]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-2900e4fee9c84658b3fbe873153cd4d6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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