Water → HCID 3904240, compound

HRID 1576911Notes

Reaction equation

HRID 1576911 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].O>CC(C)=O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:15][C:16](=[O:17])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2879P-CresolHCID 6259Phenacyl bromideHCID 11430Potassium Carbonate

Product 1

HCID 3904240HCID 3904240, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Methylphenol (5.4g; 0.05 m) and potassium carbonate (6.9g; excess) were mixed in dry acetone (40 ml.) phenacyl bromide (9.95 g.; 0.05 m) and added and the mixture was boiled under reflux with vigorous stirring for 4 hours. The mixture was cooled to room temperature, poured into iced water extracted with ether, washed with dilute sodium hydroxide solution water, dried and evaporated. The crude product was recrystallised from ethanol to give the little compound, m.p. 65°C.

Workup

  1. additionadded
  2. temperatureunder reflux
  3. extractionextracted with ether
  4. washwashed with dilute sodium hydroxide solution water
  5. customdried
  6. customevaporated
  7. customThe crude product was recrystallised from ethanol
  8. customto give the little compound, m.p. 65°C.

Sources & evidence

ORD record
ord-c72666aabcb04c8c8ffcbae764c2328e
Source dataset
uspto-grants-1976_09
Patent number
US03983164

Reaction notes

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