Hydrochloric Acid → HCID 20569941, compound

HRID 1577812Notes

Reaction equation

HRID 1577812 reaction equation
[CH3:1][C:2](=[CH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)=O)[C:3](O)=[O:4].C([O-])([O-])=O.[K+].[K+].Cl.O.[NH2:30][NH2:31]>CO>[CH3:1][C:2]1[C:3](=[O:4])[NH:30][N:31]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 24654Hydrazine hydrate (1:1)HCID 54094101HCID 54094101, compound

Product 1

HCID 20569941HCID 20569941, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

28.4 g of 2-methyl-4-(4'-fluoro-4-biphenylyl)-4-oxo-2-butenoic acid is dissolved in 100 ml of methanol; 15.4 g of K2CO3 is added and the mixture is stirred for 6 hours at 20°. It is then acidified with hydrochloric acid, 5.4 ml of hydrazine hydrate is added and the batch is boiled for 2 hours. Thereafter, it is again acidified; the solution is concentrated and cooled; and the 4-methyl-6-(4'-fluoro-4-biphenylyl)-2,3-dihydropyridazin-3-one obtained is filtered off and washed with water. m.p. 247°-248°.

Workup

  1. additionis added
  2. waitthe batch is boiled for 2 hours
  3. concentrationthe solution is concentrated
  4. temperaturecooled

Sources & evidence

ORD record
ord-5c696f02915c4fa081ff509d4cd6289a
Source dataset
uspto-grants-1981_09
Patent number
US04289774

Reaction notes

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