Butyl bromide → HCID 178454975, compound

HRID 1578051Notes

Reaction equation

HRID 1578051 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:15])[CH3:14])=[S:11].C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[CH2:23][CH2:24][CH3:25]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[N:12][C:13](=[O:15])[CH3:14])[S:11][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 12952276HCID 12952276, compound

Product 1

HCID 178454975HCID 178454975, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5.2 g (0.02 M) of N-(2,6-dichlorophenyl)-N'-acetyl-thiourea, 2.1 ml (0.015 M) of ground potassium carbonate, 3.2 ml (0.03 M) of n-butylbromide and 50 ml of acetone are boiled in a reflux under energetic shaking for 4 hours. The acetone is distilled off. The residue in the flask is washed with water and filtered. 5.8 g (90.6% of the theoretical yield) of N-(2,6-dichlorophenyl)-N'-acetyl-S-n-butylisothiourea with a melting point of 84°-89° are obtained. After recrystallization from ethanol the product has a melting point of 97°-100°.

Workup

  1. temperaturea reflux
  2. distillationThe acetone is distilled off
  3. washThe residue in the flask is washed with water
  4. filtrationfiltered

Sources & evidence

ORD record
ord-2a2aa526e9f94d58a0af317e037d9e3c
Source dataset
uspto-grants-1981_09
Patent number
US04290971

Reaction notes

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