Hydrochloric Acid → HCID 21558602, compound

HRID 1578713Notes

Reaction equation

HRID 1578713 reaction equation
[CH3:1][S:2]([CH2:4][C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:9][N:8]=1)=[O:6])=O.C(OCC)(=O)C.Cl.C([Br:28])(=O)C>ClCCl>[CH3:1][S:2][CH:4]([Br:28])[C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:9][N:8]=1)=[O:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 10482Acetyl bromideHCID 21558601HCID 21558601, compound

Product 1

HCID 21558602HCID 21558602, compoundYield 103.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A reaction identical with that of Example 3 is performed on the 3-methylsulfinylacetyl-5-phenylisoxazole (1.25 g) prepared in a manner similar to that described in Example 1 or 2 with the exception that the ethyl acetate solution of hydrogen chloride is replaced by a solution of acetyl bromide (741 mg, 6.025 milimoles) in dichloromethane (10 ml) to give 3-(2-methylthio-2-bromoacetyl)-5-phenylisoxazole (1.62 g, 103.5 %) as a crude crystalline residue.

Workup

  1. customA reaction identical with that of Example 3
  2. customprepared in a manner similar to

Sources & evidence

ORD record
ord-bccd1ca0b64645739abb080a2e59285b
Source dataset
uspto-grants-1976_02
Patent number
US03939167

Reaction notes

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