Ethanol → HCID 136353512, Verbindung

HRID 1578930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1578930
[CH3:1][C:2]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[C:8]([NH2:17])[N:7]=[C:6]([NH2:18])[N:5]=1)=O.C(O)C.Cl.[NH2:23][OH:24].C([O-])(=O)C.[Na+]>O>[CH3:1][C:2](=[N:23][OH:24])[C:4]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[C:8]([NH2:17])[N:7]=[C:6]([NH2:18])[N:5]=1

Komponenten

6

Edukt 4

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 21557324HCID 21557324, Verbindung

Produkt 1

HCID 136353512HCID 136353512, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

[2,6-Diamino-5-(p-chlorophenyl)-4-pyrimidinyl] methyl ketone (2.6 g.) was dissolved in 30 ml. of ethanol and hydroxylamine, hydrochloride (1.5 g.) and sodium acetate (2.5 g.) in 25 ml. of water was added and the mixture refluxed for 5 hours. After cooling a white precipitate separated; it was recrystallized from methanol to give 1.5 g. of the title product, m.p. 256°-259°.

Aufarbeitung

  1. temperaturethe mixture refluxed for 5 hours
  2. temperatureAfter cooling a white precipitate
  3. customseparated
  4. customit was recrystallized from methanol
  5. customto give 1.5 g

Quellen und Nachweise

ORD-Eintrag
ord-c7631447512d4c54baa95b95f680ff24
Quelldatensatz
uspto-grants-1976_02
Patentnummer
US03940393

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