Phosphate → Morphine

HRID 1581088Notes

Reaction equation

HRID 1581088 reaction equation
C1C=CC(C(O)=O)=C(C2C3C=CC(O)=CC=3OC3C=2C=CC(C=3)=O)C=1.[CH:26]1[C:42]2[CH2:41][C@H:40]3[N:43]([CH2:45][CH2:46][C@@:32]45[C@H:39]3[CH:38]=[CH:37][C@H:35]([OH:36])[C@@H:33]4[O:34][C:30]([C:31]=25)=[C:28]([OH:29])[CH:27]=1)[CH3:44].P([O-])([O-])([O-])=O.C(O)C(N)(CO)CO.Cl.C(O)C(N)(CO)CO.CN1[C@@H]2CC3C=CC(OC)=C4O[C@H]5[C@@H](O)C=C[C@@H]2[C@]5(C=34)CC1>O>[CH:26]1[C:42]2[CH2:41][C@H:40]3[N:43]([CH2:45][CH2:46][C@@:32]45[C@H:39]3[CH:38]=[CH:37][C@H:35]([OH:36])[C@@H:33]4[O:34][C:30]([C:31]=25)=[C:28]([OH:29])[CH:27]=1)[CH3:44]

Participants

7

Reactant 5

HCID 1061PhosphateHCID 6503Tris(hydroxymethyl)aminomethaneHCID 93573Tromethamine hydrochlorideHCID 5284371CodeineHCID 86733026HCID 86733026, compound

Product 1

HCID 5288826Morphine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

The reagents which were employed were as follows: FLUMO (fluorescein-morphine conjugate) was 3 × 10-6M in water; antifluorescein, was 5.6 × 10-6M in binding sites, in water, 0.05M phosphate, pH 8.0; antimorphine was 2 × 10-4M in binding sites, 0.05M Tris-HCl, pH 8.0, in saline solution; buffer was Tris/saline 0.05M/1, pH 8.0. Opiate solutions had 1,000μg/ml per ml of codeine.

Sources & evidence

ORD record
ord-d12a8160b4394e27ae530a4bfc28b385
Source dataset
uspto-grants-1976_01
Patent number
US03935074

Reaction notes

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