Benzyl Chloride → HCID 15619940, compound

HRID 1581135Notes

Reaction equation

HRID 1581135 reaction equation
Cl.[OH:2][CH2:3][C:4]1[CH:5]=[C:6]([OH:11])[C:7]([CH3:10])=[N:8][CH:9]=1.[H-].[Na+].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CN(C)C=O>[CH2:14]([O:11][C:6]1[C:7]([CH3:10])=[N:8][CH:9]=[C:4]([CH2:3][OH:2])[CH:5]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 7503Benzyl ChlorideHCID 24758Sodium hydrideHCID 1991873-Pyridinemethanol, 5-hydroxy-6-methyl-, hydrochloride

Product 1

HCID 15619940HCID 15619940, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a solution of 1.7 g. of 5-hydroxymethyl-2-methyl-3-pyridinol hydrochloride in 10 ml. of dimethylformamide was added a solution of 0.9 g. of 50% sodium hydride in 6 ml. of dimethylformamide. The mixture was stirred at room temperature for 3 hours and to the solution was added 1.25 g. of benzyl chloride and additional stirring was continued overnight at room temperature.

Workup

  1. additionwas added 1.25 g
  2. waitwas continued overnight at room temperature

Sources & evidence

ORD record
ord-c8e10cb42a94451b94bf2a89e7eeab74
Source dataset
uspto-grants-1976_01
Patent number
US03935311

Reaction notes

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