Potassium Carbonate → HCID 178447925, compound

HRID 1583237Notes

Reaction equation

HRID 1583237 reaction equation
FC1C=C([C@H]2CC[C@H](CCCCC)CC2)C=C(F)C=1O.C([O-])([O-])=O.[K+].[K+].C(I)CCCCC.[F:34][C:35]1[CH:40]=[C:39]([C@H:41]2[CH2:46][CH2:45][C@H:44]([CH2:47][CH2:48][CH2:49]CC)[CH2:43][CH2:42]2)[CH:38]=[C:37]([F:52])[C:36]=1[O:53][CH2:54]CCCCC>CN(C)C=O>[F:34][C:35]1[CH:40]=[C:39]([C@H:41]2[CH2:42][CH2:43][C@H:44]([CH2:47][CH2:48][CH3:49])[CH2:45][CH2:46]2)[CH:38]=[C:37]([F:52])[C:36]=1[O:53][CH3:54]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 125271-IodohexaneHCID 178444374HCID 178444374, compoundHCID 178444967HCID 178444967, compound

Product 1

HCID 178447925HCID 178447925, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 28.2 g of 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-phenol, 6.9 g of K2CO3, 25 g of hexyl iodide and 250 ml of dimethylformamide is heated at 80° for 16 hours, while stirring, and is then cooled and worked up in the usual manner. This gives 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-1-hexoxybenzene.

Workup

  1. temperatureis heated at 80° for 16 hours
  2. temperatureis then cooled

Sources & evidence

ORD record
ord-9a326e45977b499d8783d3a34d3d445a
Source dataset
uspto-grants-1985_11
Patent number
US04551264

Reaction notes

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