反应详情

By the method of Example 6, using a reflux time of 1 hour prior to addition of a sodium iodide, piroxicam (2.00 g, 6.0 mmol) and alpha-chloroethyl methyl carbonate (2.50 g, 18.1 mmol) were converted to chromatographed title product as a yellow solid which was crystallized from isopropyl alcohol (660 mg, 1.5 mmol, 25.0%): mp 150°-151° C.; IR (KBr) 1757, 1677 cm-1 ; 1H NMR (CDCl3) delta 1.75 (d, J=6 Hz, 3H), 3.12 (s, 3H), 3.65 (s, 3H), 6.35 (q, J=6 Hz, 1H), 7.07-7.18 (m, 1H), 7.65-7.95 (m, 5H), 8.30-8.42 (m, 2H), 9.42 (br s, 1H); precise mass calcd for C19H19N3O7S m/e 433.0944, found 433.1004.

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2. customto chromatographed title product as a yellow solid which