反应详情

Sodium hydride (0.24 g; 60% in oil) was suspended in 30 ml of dry tetrahydrofuran, and then 1.0 g of 3-(2-fluoroethoxy)benzyl alcohol was added. The mixture was stirred at 50° to 60° C. for 30 minutes, and 1.7 g of benzyl bromide was added. The mixture was heated under reflux for 3 hours. The reaction mixture was cooled to room temperature, poured into water, and extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure. The resulting crude ether was purified by silica gel (50 g) column chromatography (developing solvent: toluene) to give 1.2 g of 3-(2-fluoroethoxy)benzyl benzyl ether.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 3 hours
3. extractionextracted with toluene
4. washThe toluene layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customToluene was evaporated under reduced pressure
7. customThe resulting crude ether was purified by silica gel (50 g) column chromatography (developing solvent: toluene)