反应详情

To a solution of the compound of Example 38 (4.00 g, 0.0110 mole) in 10 mL of ethyl acetate at room temperature was added 5N HCl in ethyl acetate (50 mL, freshly prepared, 0.25 mole) in one portion. The solution was stirred for 3 hrs, solvent was evaporated, CH2Cl2 was added and the solvents were reevaporated. The residue was pumped at <1 mm Hg on a vacuum pump for 24 hours to afford 3.37 g (~Quantitative crude yield) of product as a colorless foam. TLC (silica gel; CH2Cl2, methanol, conc. NH4OH: 27:3:1): Rf=0.32.

1. customfreshly prepared
2. customsolvent was evaporated
3. additionCH2Cl2 was added
4. customthe solvents were reevaporated
5. waitThe residue was pumped at <1 mm Hg on a vacuum pump for 24 hours
6. customto afford
7. custom3.37 g (~Quantitative crude yield) of product as a colorless foam