O-Cresol → HCID 21217658, compound

HRID 1586007Notes

Reaction equation

HRID 1586007 reaction equation
[Na].Cl[C:3]1[N:4]=[N:5][C:6]([S:9][CH2:10][CH:11]=[CH2:12])=[CH:7][CH:8]=1.[C:13]1([CH3:20])[C:18]([OH:19])=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:20][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=1[O:19][C:3]1[N:4]=[N:5][C:6]([S:9][CH2:10][CH:11]=[CH2:12])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 335O-CresolHCID 5360545SodiumHCID 212176673-Chloro-6-[(prop-2-en-1-yl)sulfanyl]pyridazine

Product 1

HCID 21217658HCID 21217658, compound

Conditions

Temperature
100 °C

Procedure

0.23 g(0.01 mol) of metallic sodium was dissolved in 30 ml of dry o-cresol. To the resulting solution was added 1.87 g(0.01 mol) of 3-chloro-6-allylthiopyridazine. The reaction solution was stirred for 5 hours at 100±5° C. and then treated according to the same manner as Example 23 to obtain the title compound as a pale white needle crystal.

Workup

  1. additiontreated

Sources & evidence

ORD record
ord-1722e8d2ed124226b4f09c7736fdd749
Source dataset
uspto-grants-1999_08
Patent number
US05942511

Reaction notes

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