反应详情

A mixture of 25 g (0.126 mol) of phenothiazine, 33 g (0.151 mol) of p-iodotoluene, 4 g (0.025 mol) of copper sulfate, 23 g of potassium carbonate, and 200 ml of diisopropylbenzene was reacted at 180° C. for 3 hours and then at 200° C. for 1 day. The mixture was then cooled and filtered through a Celite. The filtrate was concentrated, and the residual crystals were recrystallized from an ethanol/ethyl acetate mixed solvent to obtain 27.5 g of 10-p-tolylphenothiazine (4b).

1. customwas reacted at 180° C. for 3 hours
2. temperatureThe mixture was then cooled
3. filtrationfiltered through a Celite
4. concentrationThe filtrate was concentrated
5. customthe residual crystals were recrystallized from an ethanol/ethyl acetate mixed solvent