反应详情

温度

80 °C

47.8 g(0.25 mol) of 2,4-dichlorobenzoic acid are dissolved in 500 g of dimethylacetamide, 26.3 g (0.35 mol) of glycine and 1.7 g (7.5 mmol) of basic copper carbonate are added and the mixture is heated to 80° C. After addition of 24 g (0.6 mol) of NaOH and 22.5 g (0.16 mol) of K2CO3, the mixture is heated at 140° C. for 5 h. It is cooled to room temperature, diluted with 200 ml of water and adjusted to pH 2 with hydrochloric acid, and the crystalline product is filtered off. 43.9 g (0.19 mol, 77%) of N-carboxymethylene-4-chloroanthranilic acid are obtained.

1. temperaturethe mixture is heated at 140° C. for 5 h
2. temperatureIt is cooled to room temperature
3. filtrationthe crystalline product is filtered off