Sodium hydride → HCID 19759871, compound

HRID 1586863Notes

Reaction equation

HRID 1586863 reaction equation
[CH3:1][C:2]1([C:12]([OH:14])=[O:13])[S:9](=[O:11])(=[O:10])[C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH2:3]1.S1(=O)(=O)C2SC=CC=2[CH2:17][CH:16]1C(O)=O.[H-].[Na+].C(I)CC>CN(C=O)C>[CH2:1]([C:2]1([C:12]([OH:14])=[O:13])[S:9](=[O:11])(=[O:10])[C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH2:3]1)[CH2:16][CH3:17]

Participants

6

Reactant 4

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 19759880HCID 19759880, compoundHCID 19759891HCID 19759891, compound

Product 1

HCID 19759871HCID 19759871, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared in substantially the same way was 2,3-dihydro-2-methylthieno[2,3-b]thiophene-2-carboxylic acid-1,1-dioxide. Thus, 2,3-dihydrothieno[2,3-b]thiophene-2-carboxylic acid-1,1-dioxide (10.5 g, 0.048 mol) when reacted with NaH (5.76 g, 60% dispersion in oil) and n-propyl iodide (14 mL, 0.047 mol) in DMF (200 mL) gave the title compound as a gum (11.3 g, 90%).

Workup

  1. customThe title compound was prepared in substantially the same way

Sources & evidence

ORD record
ord-cef4fcc76fc243c6b8fbda721f093ce5
Source dataset
uspto-grants-1993_06
Patent number
US05216020

Reaction notes

Loading…